Heterogeneous catalysts showing high catalytic performance, structural stability, and low toxicity, are greatly required for efficiently degenerate organic pollutants in waste water in advanced oxidation processes (AOPs). In this paper, mesoporous heterogeneous catalyst Cu-Mn/TiO2 composites has been successfully prepared, which has a stable crystalline mesostructure TiO2 as the support, and well-dispersed Cu-Mn oxides as catalytic active sties. The Cu, Mn content is measured to be 5.7 and 6.0 wt.%, and the BET surface area is measured to be 97 m2/g with its pore size of ~ 6.0 nm and pore volume of 0.15 cm3g-1. Using the prepared Cu-Mn/TiO2 composites as the AOPs catalyst for degeneration of Acid Red 1, it can efficiently (>99%) degenerates the model pollutant in water with only 90 min. Compared with homogeneous catalysts, it can retain its catalytic performance over a wide pH range (3 - 9) and can be recycled for at least five times meanwhile still possessing the decolorization efficiency of 89%. By analyzing the catalytic process, a possible catalytic procedure for degradation of Acid Red 1 has been proposed. Furthermore, using bulk Cu-Mn oxides, Cu-Mn/P25, and Cu-Mn/SBA-15 as reference catalysts, we propose that the excellent catalytic performance of Cu-Mn/TiO2 could be ascribed to the anatase mesoporous TiO2, which not only offers a stable matrix with high surface area for Cu-Mn catalysts, but also serves as a kind of catalytic promoter for the synergistic catalytic degeneration of Acid Red 1.