Royal Society of Chemistry, Dalton Transactions, 9(44), p. 4355-4361, 2015
DOI: 10.1039/c4dt03758h
Full text: Unavailable
Enzyme and voltage stimuli are more biological compatibility in the field of stimuli-responsive system and the release system based on β-cyclodextrin (CD) and ferrocene (Fc) has attracted much attention. Herein, mesoporous silica nanoparticles (MSNs) have been functionalized with the ferrocenyl moiety (Fc) which interacts with β-cyclodextrin (β-CD) to form an inclusion complex on the opening of the pores. The size effect of the inclusion complex makes the barriers on the opening of the pores. Based on these characteristics, the MSNs with nanovalves have been developed to be a release system. The release system shows a clear response to Heme protein (horseradish peroxidase or hemoglobin) and H2O2, glucose oxidase (GOD) with horseradish peroxidase (HRP) and glucose, or +1.5 V voltage based on the oxidation stimulus mechanism. Modulating the amount of enzyme or the discretion of the voltage makes the release system achieve a controlled one.