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Nature Research, Nature Communications, (6), p. 7208

DOI: 10.1038/ncomms8208

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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

Journal article published in 2015 by Harmen H. M. Draisma, René Pool ORCID, Michael Kobl, Rick Jansen, Ann-Kristin Petersen, Anika A. M. Vaarhorst, Idil Yet, Toomas Haller, Ayşe Demirkan ORCID, Tõnu Esko ORCID, Gu Zhu, Stefan Boehringer, Stefan Böhringer, Marian Beekman, Jan Bert van Klinken and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7, 478 individuals of European descent, we find 4, 068 genome-and metabolome-wide significant (Z-test, P