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Nature Research, Nature Communications, (6), p. 7208

DOI: 10.1038/ncomms8208



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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Data provided by SHERPA/RoMEO


Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analyses for variation in the blood serum levels of 129 metabolites as measured by the Biocrates metabolomic platform. In a discovery sample of 7, 478 individuals of European descent, we find 4, 068 genome-and metabolome-wide significant (Z-test, P