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American Chemical Society, Organic Letters, 10(17), p. 2538-2541, 2015

DOI: 10.1021/acs.orglett.5b01080

Wiley-VCH Verlag, ChemInform, 38(46), p. no-no, 2015

DOI: 10.1002/chin.201538200

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ChemInform Abstract: Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum.

Journal article published in 2015 by Jun-Jie Han, Li Bao, Qiao Tao, Yi-Jian Yao, Xing-Zhong Liu, Wen-Bing Yin, Hong-Wei Liu
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Ten new ergosteroids, gloeophyllins A-J (1-10), have been isolated from the solid cultures of Gloeophyllum abietinum. The absolute configurations of 1, 2, and 9 were determined by X-ray crystallographic analysis. Compound 1 has a rare C-nor-D-homosteroid skeleton. Compound 9 possesses an unusual ergostane skeleton having a 10-oxabicyclo [4.3.1] decane moiety replacing 6/5 fused C/D rings. Compound 10 represents the first ergosteroid featuring the cleavage of a C8-C14 bond. The cytotoxicity of 1-10 was tested against the human cancer cell lines K562 and HCT116. The biosynthetic pathway for 1-10 is postulated.