Published in
Wiley, Angewandte Chemie International Edition, 43(48), p. 8042-8046, 2009
Wiley, Angewandte Chemie, 43(121), p. 8186-8190, 2009
Links
Tools
Total Synthesis of Pentabromo- and Pentachloropseudilin, and Synthetic Analogues-Allosteric Inhibitors of Myosin ATPase
,
Dietmar J. Manstein,
Herwig O. Gutzeit,
Hans-Joachim Knölker
Full text: Download
Abstract
Stopping myo: The total syntheses of the title compounds have been achieved using a highly efficient silver(I)- catalyzed cyclization of N-tosyl-homopropargylamines. The pseudilin derivatives represent a novel class of myosin inhibitors. A new allosteric binding pocket of the Dictyostelium myosin-2 motor domain has been identified for pentabromopseudilin (1) by using an X-ray crystal structure determination of the inhibitor-protein complex.