American Chemical Society, Organic Letters, 4(8), p. 741-744, 2006
DOI: 10.1021/ol053001a
Wiley-VCH Verlag, ChemInform, 26(37), 2006
Full text: Unavailable
[reaction: see text] A novel, biomimetic concept for the direct reductive amination of ketones is described that relies on selective imine activation by hydrogen bond formation. The mild, acid- and metal-free process requires only catalytic amounts of thiourea as hydrogen bond donor and utilizes the Hantzsch ester for transfer hydrogenation. The method allows the efficient synthesis of structurally diverse amines.