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American Academy of Neurology (AAN), Neurology, 5(83), p. 476-476, 2014

DOI: 10.1212/01.wnl.0000453101.10188.87

American Academy of Neurology (AAN), Neurology, 4(82), p. 332-339, 2014

DOI: 10.1212/wnl.0000000000000063

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Alcohol consumption and cognitive decline in early old age

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

To examine the association between alcohol consumption in midlife and subsequent cognitive decline. Data are from 5,054 men and 2,099 women from the Whitehall II cohort study with a mean age of 56 years (range 44-69 years) at first cognitive assessment. Alcohol consumption was assessed 3 times in the 10 years preceding the first cognitive assessment (1997-1999). Cognitive tests were repeated in 2002-2004 and 2007-2009. The cognitive test battery included 4 tests assessing memory and executive function; a global cognitive score summarized performances across these tests. Linear mixed models were used to assess the association between alcohol consumption and cognitive decline, expressed as z scores (mean = 0, SD = 1). In men, there were no differences in cognitive decline among alcohol abstainers, quitters, and light or moderate alcohol drinkers (