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BioMed Central, BMC Medical Genetics, 1(16), 2015

DOI: 10.1186/s12881-015-0253-3

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Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: A case-control study

Journal article published in 2015 by Mette Hollensted, Tarunveer S. Ahluwalia, Christian Theil Have ORCID, Niels Grarup, Tenna Ruest, Cilius Esmann Fonvig ORCID, Tenna Ruest Haarmark Nielsen, Caecilie Trier, Lavinia Paternoster ORCID, Oluf Pedersen, I. A. Thorkild, Jens-Christian Holm, Thorkild I. A. Sørensen, Torben Hansen
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Background: Childhood obesity is a highly heritable disorder, for which the underlying genetic architecture is largely unknown. Four common variants involved in inflammatory-adipokine triggering (IL6 rs2069845, LEPR rs1137100, NAMPT rs3801266, and AMD1 rs2796749) have recently been associated with obesity and related traits in Indian children. The current study aimed to examine the effect of these variants on risk of childhood/juvenile onset obesity and on obesity-related quantitative traits in two Danish cohorts.