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Elsevier, Cytokine, 2(69), p. 240-247

DOI: 10.1016/j.cyto.2014.06.010

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Elevated biomarkers of endothelial dysfunction/activation at ICU admission are associated with sepsis development

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This paper is available in a repository.

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Abstract

Widespread endothelial activation and dysfunction often precede clinical sepsis. Several endothelium-related molecules have been investigated as potential biomarkers for early diagnosis and/or prognosis of sepsis, providing different results depending on study designs. Such factors include endothelial adhesion molecules like E- and P-selectin, and the intercellular adhesion molecule-1, vascular endothelial cadherin, growth factors such as Angiopoietin-1 and -2 and vascular endothelial growth factor, as well as von Willebrand factor antigen. We sought to investigate whether circulating biomarkers of endothelial activation/dysfunction measured at ICU admission are associated with subsequent sepsis development.