Dissemin is shutting down on January 1st, 2025

Published in

Critical Reviews in Oral Biology & Medicine, 3(13), p. 220-228

DOI: 10.1177/154411130201300302

Links

Tools

Export citation

Search in Google Scholar

Chemotactic signaling pathways in neutrophils: From receptor to actin assembly

Journal article published in 2002 by Gregor Cicchetti, Philip G. Allen, Michael Glogauer ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

In this review, we present an overview of the signaling elements between neutrophil chemotactic receptors and the actin cytoskeleton that drives cell motility. From receptor-ligand interactions, activation of heterotrimeric G-proteins, their downstream effectors PLC and PI-3 kinase, the activation of small GTPases of the Rho family, and their regulation of particular cytoskeletal regulatory proteins, we describe pathways specific to the chemotaxing neutrophil and elements documented to be important for neutrophil function.