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Elsevier, Bioorganic and Medicinal Chemistry, 15(23), p. 4681-4687

DOI: 10.1016/j.bmc.2015.05.055

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Modified quaternary ammonium salts as potential antimalarial agents

Journal article published in 2015 by Nicoletta Basilico, Mara Migotto ORCID, Denise Patoinewende Ilboudo, Donatella Taramelli, Riccardo Stradi, Elena Pini ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

A series of new quaternary ammonium salts containing a polyconjugated moiety has been synthesized and characterized; their biological activity as potential antimalarial agents was investigated, as well. All compounds were screened against chloroquine resistant W-2 (CQ-R) and chloroquine sensitive, D-10 (CQ-S) strains of Plasmodium falciparum showing IC50 in the submicromolar range and low toxicity against human endothelial cells.