Published in

Springer Nature [academic journals on nature.com], Journal of Antibiotics, 5(60), p. 328-331, 2007

DOI: 10.1038/ja.2007.43

Wiley-VCH Verlag, ChemInform, 46(38), 2007

DOI: 10.1002/chin.200746189

Links

Tools

Export citation

Search in Google Scholar

The First Hydroxylated Archazolid from the Myxobacterium Cystobacter violaceus: Isolation, Structural Elucidation and V-ATPase Inhibition

Journal article published in 2007 by Dirk Menche, Jorma Hassfeld, Heinrich Steinmetz, Markus Huss, Helmut Wieczorek, Florenz Sasse
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The novel macrocyclic polyketide, 10-hydroxymethyl-archazolid-7-O-beta-D-glucopyranoside (archazolid D), was obtained from the myxobacterium Cystobacter violaceus. The structure of this first hydroxylated archazolid was determined by spectroscopic analysis, in particular by HMBC, HMQC, and ROESY NMR investigations, and by degradation. This novel metabolite was evaluated for growth inhibition of murine connective tissue cells and V-ATPase inhibition in comparison to other known archazolids.