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Wiley, Angewandte Chemie International Edition, 26(47), p. 4858-4861, 2008

DOI: 10.1002/anie.200800468

Wiley, Angewandte Chemie, 26(120), p. 4936-4939, 2008

DOI: 10.1002/ange.200800468

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A Metal-Mediated Conformational Switch Controls G-Quadruplex Binding Affinity

Journal article published in 2008 by David Monchaud, Laurent Lacroix ORCID, Peng Yang ORCID, Marie-Paule Teulade-Fichou, Jean-Louis Mergny ORCID
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This paper is available in a repository.

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Abstract

(Figure Presented) Control by copper: CuII ions modulate the quadruplex affinity of the high-affinity ligand 360A and denaturate the folded quadruplex form of DNA 22AG to an unfolded form. So removal of copper through complexation enables the cycling of both 360A quadruplex affinity and quadruplex unfolding.