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Lippincott, Williams & Wilkins, PAIN, 2(157), p. 418-428, 2016

DOI: 10.1097/j.pain.0000000000000332

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Role of adult hippocampal neurogenesis in persistent pain

This paper is available in a repository.
This paper is available in a repository.

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Abstract

The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning, emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet the role of AHN in development of persistent pain has remained unexplored. Here we test the influence of AHN in post-injury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN mediated hippocampal learning mechanisms are involved in emergence of persistent pain.