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The Royal Society, Biology Letters, 4(11), p. 20141031, 2015

DOI: 10.1098/rsbl.2014.1031

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How to calculate the non-synonymous to synonymous rate ratio of protein-coding genes under the Fisher-Wright mutation-selection framework

Journal article published in 2015 by Mario Dos Reis ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

First principles of population genetics are used to obtain formulae relating the non-synonymous to synonymous substitution rate ratio to the selection coefficients acting at codon sites in protein-coding genes. Two theoretical cases are discussed and two examples from real data (a chloroplast gene and a virus polymerase) are given. The formulae give much insight into the dynamics of non-synonymous substitutions and may inform the development of methods to detect adaptive evolution.