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Elsevier, Kidney International, 3(88), p. 431-433

DOI: 10.1038/ki.2015.124

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The battlefield at arteriovenous crossroads: Invading arterial smooth muscle cells occupy the outflow tract of fistulas

Journal article published in 2015 by Joris I. Rotmans ORCID, Taisiya Bezhaeva
This paper is available in a repository.
This paper is available in a repository.

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Abstract

There is an ongoing debate about the anatomical origin of the neointimal cells that are responsible for venous stenotic lesions in arteriovenous fistulas. Liang and co-workers show that vascular smooth muscle cells from the feeding artery contribute substantially to venous intimal hyperplasia in a murine AVF model. In addition, they show that increased Notch signaling is the driving force behind FSP-1-mediated migration of these cells to the venous outflow tract.