Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 22(12), p. 3744-3754
DOI: 10.1039/c4ob00220b
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Aryl ethynyl anthraquinones: A useful platform for targeting telomeric G-quadruplex structures
Journal article published in 2014 by
Claudia Percivalle,
Claudia Sissi,
Maria Laura Greco,
Caterina Musetti,
Angelica Mariani,
Anna Artese,
Giosuè Costa 
,
Maria Lucia Perrore,
Stefano Alcaro,
and Mauro Freccero
,
Maria Lucia Perrore,
Stefano Alcaro,
and Mauro Freccero
This paper is made freely available by the publisher.
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Abstract
Aryl ethynyl anthraquinones have been synthesized by Sonogashira cross-coupling and evaluated as telomeric G-quadruplex ligands, by the FRET melting assay, circular dichroism, the DNA synthesis arrest assay and molecular docking. Both the binding properties and G-quadruplex vs. duplex selectivity are controlled by the structures of the aryl ethynyl moieties.