Royal Society of Chemistry, RSC Advances, 14(5), p. 10768-10772, 2015
DOI: 10.1039/c4ra14811h
Wiley-VCH Verlag, ChemInform, 26(46), p. no-no, 2015
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One-pot, atom-economical, catalyst-free and tri-component domino reactions are applied to the diversity-oriented synthesis (DOS) of disubstituted piperazine derivatives under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals, liquid crystals, complexes, etc. Because of its operational simplicity and convenience, it may be suitable for application in large-scale synthesis.