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BioScientifica, European Journal of Endocrinology, 2(171), p. 193-198, 2014

DOI: 10.1530/eje-13-0847

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Elevated serum levels of free triiodothyronine in adolescent boys with gynaecomastia compared with controls

Journal article published in 2014 by Mikkel G. Mieritz, Kaspar Sorensen, Lise Aksglaede ORCID, Annette Mouritsen, Casper P. Hagen, Linda Hilsted, Anna-Maria Andersson, Anders Juul ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

ObjectivePubertal gynaecomastia is a frequent phenomenon occurring in 20–40% of otherwise healthy adolescent boys. Little is known about the aetiology of pubertal gynaecomastia. Markedly elevated thyroid hormone levels in adults with hyperthyroidism are associated with gynaecomastia.DesignA cross-sectional examination of 444 healthy boys with and without pubertal gynaecomastia.MethodsWe evaluated TSH, triiodothyronine (T3), thyroxine (T4), free T4 and free T3 in a cohort of healthy boys with and without pubertal gynaecomastia.ResultsBoys with gynaecomastia had significantly higher serum free T3, even after correction for age, BMI and pubertal stage. After inclusion of IGF1 in the model the differences disappeared. TSH, T4, free T4 and T3 did not differ between the groups.ConclusionsWe speculate that the GH/IGF1 axis and thyroid hormones interact and influence the development of pubertal gynaecomastia.