Control and stabilization of viscous fingering of immiscible fluids impacts a wide variety of pressure-driven multiphase flows. We report theoretical and experimental results on a time-dependent control strategy by manipulating the gap thickness bðtÞ in a lifting Hele-Shaw cell in the power-law form bðtÞ ¼ b 1 t 1=7. Experimental results show good quantitative agreement with the predictions of linear stability analysis. By choosing the value of a single time-independent control parameter, we can either totally suppress the viscous fingering instability or maintain a series of nonsplitting viscous fingers during the fluid displacement process. In addition to the gap thickness of a Hele-Shaw cell, time-dependent control strategies can, in principle, also be placed on the injection rate, viscosity of the displaced fluid, and interfacial tension between the two fluids.