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American Heart Association, Circulation: Cardiovascular Genetics, 3(4), p. 327-329, 2011

DOI: 10.1161/circgenetics.111.960443

Nature Research, Nature Genetics, 4(43), p. 333-338

DOI: 10.1038/ng.784

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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

Journal article published in 2011 by Samani N.-J. the CARDIoGRAM Consortium, Am van Rij, Mýhleisen Tw, Heribert Schunkert, J. Wouter Jukema, W. H. Wilson Tang, Ir R. Konig, Muredach P. Reilly, Sekar Kathiresan, Af F. R. Stewart, Tl L. Assimes, Anand Ss, Boekholdt Sm, Ir R. König, Hilma Holm and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

We performed a meta-analysis of 14 genome-wide association studies of coronary artery disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of European descent followed by genotyping of top association signals in 56,682 additional individuals. This analysis identified 13 loci newly associated with CAD at P < 5 × 10⁻⁸ and confirmed the association of 10 of 12 previously reported CAD loci. The 13 new loci showed risk allele frequencies ranging from 0.13 to 0.91 and were associated with a 6% to 17% increase in the risk of CAD per allele. Notably, only three of the new loci showed significant association with traditional CAD risk factors and the majority lie in gene regions not previously implicated in the pathogenesis of CAD. Finally, five of the new CAD risk loci appear to have pleiotropic effects, showing strong association with various other human diseases or traits.