We report on the existence and nature of Holocene solar and climatic variations on centennial to millennial time-scales. We introduce a new solar activity proxy, based on nitrate (NO 3 −) concentration from the Talos Dome ice core, East Antarctica. We also use a new algorithm for computing multiple-cross wavelet spectra in time–fre-quency space that is generalized for multiple time series (beyond two). Our results provide a new interpretive framework for relating Holocene solar activity variations on centennial to millennial timescales to co-varying cli-mate proxies drawn from a widespread area around the globe. Climatic proxies used represent variation in the North Atlantic Ocean, Western Pacific Warm Pool, Southern Ocean and the East Asian monsoon regions. Our wavelet analysis identifies fundamental solar modes at 2300-yr (Hallstattzeit), 1000-yr (Eddy), and 500-yr (unnamed) periodicities, leaves open the possibility that the 1500–1800-yr cycle may either be fundamental or derived, and identifies intermediary derived cycles at 700-yr and 300-yr that may mark rectified responses of the Atlantic thermohaline circulation to external solar modulation and pacing. Dating uncertainties suggest that the 1500-yr and 1800-yr cycles described in the literature may represent either the same or two separate cycles, but in either case, and irrespective too of whether it is a fundamental or derived mode in the sense of Dima and Lohmann (2009), the 1500–1800-yr periodicity is widely represented in a large number of paleoclimate proxy records. It is obviously premature to reject possible links between changing solar activity at these multiple scales and the variations that are commonly observed in paleoclimatic records.