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Springer (part of Springer Nature), Analytical and Bioanalytical Chemistry, 20(407), p. 6217-6220

DOI: 10.1007/s00216-015-8779-y

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Silica-based 2-(N,N-dimethylamino)-1,3-propanediol hydrophilic interaction liquid chromatography stationary phase for separating cephalosporins and carbapenems

Journal article published in 2015 by Wei Yin, Lingping Cheng, Huihui Chai, Ruiqiang Guo, Renhua Liu, Changhu Chu, John A. Palasota, Xiaohui Cai
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A silica-based stationary phase bearing both hydrophilic hydroxyl and amino groups was developed by covalently bonding a small molecular N,N-dimethylamino 1,3-propanediol moiety onto silica beads via copper(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition (CuAAC). This new stationary phase showed good HILIC characteristics and high column efficiency (the theoretical plate number is up to 37000 plates m(-1) in the case of inosine) in the separation of polar compounds, such as nucleosides and bases, organic acids, cephalosporins, and carbapenems.