RC buildings constitute the prevailing type of construction in earthquake-prone region like Kathmandu valley. Most of these building constructions were based on conventional methods. In this context, the present paper studied the seismic behaviour of existing RC buildings in Kathmandu valley. For this, four representative building structures with different design and construction, namely a building: (a) representing the non-engineered construction (RC1 and RC2) and (b) engineered construction (RC3 and RC4) has been selected for analysis. The dynamic properties of the case study building models are analyzed and the corresponding interaction with seismic action is studied by means of non-linear analyses. The structural response measures such as capacity curve, inter-storey drift and the effect of geometric non-linearities are evaluated for the two orthogonal directions. The effect of plan and vertical irregularity on the performance of the structures was studied by comparing the results of two engineered buildings. This was achieved through non-linear dynamic analysis with a synthetic earthquake subjected to X, Y and 45° loading directions. The nature of the capacity curve represents the strong impact of the P-delta effect, leading to a reduction of the global lateral stiffness and reducing the strength of the structure. The non-engineered structures experience inter-storey drift demands higher than the engineered building models. Moreover, these buildings have very low lateral resistant, lesser the stiffness and limited ductility. Finally, a seismic safety assessment is performed based on the standard drift limits. Result indicates that most of the existing buildings in Nepal exhibit inadequate seismic performance.