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Molecular & Cellular Oncology, p. 00-00

DOI: 10.1080/23723556.2016.1140262

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Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer

Journal article published in 2016 by Mohammad Asim, Charlie E. Massie ORCID, David E. Neal
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.