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F1000Research, F1000Research, (4), p. 1310, 2015

DOI: 10.12688/f1000research.7334.1

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HiCUP: pipeline for mapping and processing Hi-C data

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

HiCUP is a pipeline for processing sequence data generated by Hi-C and Capture Hi-C (CHi-C) experiments, which are techniques used to investigate three-dimensional genomic organisation. The pipeline maps data to a specified reference genome and removes artefacts that would otherwise hinder subsequent analysis. HiCUP also produces an easy-to-interpret yet detailed quality control (QC) report that assists in refining experimental protocols for future studies. The software is freely available and has already been used for processing Hi-C and CHi-C data in several recently published peer-reviewed studies.