The newly fledged nanotechnologies offer opportunities for social development, but uncertainties prevail about their impact on human and environmental health. There is still a huge gap between technological progress and research into the health and safety aspects of nanomaterials. This is clear from the quantity of nanoproducts already on the market — more than 600 — and the public and private funds dedicated to the development of nanotechnologies, which are almost a hundred times those available for research into their effects on health and safety. Estimates have it that by 2014, nanotechnologies will be widely used in our society and ten million new jobs will be created. Therefore, it becomes essential to plan an integrated approach to specific risk analysis at work. The following gaps and needs come to light: limited information, difficulties in relating nanotechnologies and production of nanomaterials to specific areas of application, efforts required to assess the hazards posed by nanomaterials in realistic exposure conditions, ethical issues about nanotechnology in the workplace likely to arise from today’s knowledge about the hazards of nanomaterials and the risks they may pose to workers. An integrated approach to research, cooperation, and communication strategies is essential if we are to direct our efforts toward responsible and sustainable growth of nanotechnologies.