Diabetic foot (DF) is a chronic and highly disabling complication of diabetes. Prevalence of peripheral arterial disease (PAD) is high in diabetic patients and, associated or not with peripheral neuropathy (PN), can be found in 50% of cases of DF. It is worth pointing out that the number of major amputations in diabetic patients it is still very high. Many PAD diabetic patients are not revascularized due lack of technical expertise of, ever worse, negative believes because of poor experience. This is despite the progresses obtained in the technics of distal revascularization that nowadays allow to re-open distal arteries of the leg and of the foot . Italy has one of the lowest prevalence rates of major amputations in Europe and we have a long tradition in the field of limb salvage with aggressive approach in debridment, antibiotic therapy and distal revascularization. Therefore we believe it is appropriate to produce a consensus document concerning the treatment of PAD and limb salvage in diabetic patients, based on the Italian experience in this field, to share with the scientific community.