Published in
American Chemical Society, Organic Letters, 6(13), p. 1532-1535, 2011
DOI: 10.1021/ol200221n
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Solomonamides A and B, New Anti-inflammatory Peptides from Theonella swinhoei
,
Simona De Marino,
Valentina Sepe,
Maria Valeria D’Auria,
Giuseppe Bifulco,
Cecile Débitus,
Mariarosaria Bucci,
Valentina Vellecco,
Angela Zampella
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- Must obtain written permission from Editor
- Must not violate ACS ethical Guidelines
Abstract
Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey's method, QM J based analysis, and DFT J/(13)C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.