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Elsevier, Journal of Allergy and Clinical Immunology, 4(137), p. 1026-1035, 2016

DOI: 10.1016/j.jaci.2015.08.050

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Early growth characteristics and the risk of reduced lung function and asthma: A meta-analysis of 25,000 children

Journal article published in 2015 by den Dekker Ht, Herman T. den Dekker, Agnes M. M. Sonnenschein-Van der Voort, Johan C. de Jongste, Sonnenschein van der Voort Am, Isabella Anessi-Maesano, de Jongste Jc, S. Hasan Arshad, Henrique Barros, Caroline S. Beardsmore, S. Hasan Arshad, Hans Bisgaard, Sofia Correia Phar, Leone Craig, Graham Devereux and other authors.
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This paper is available in a repository.

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Abstract

BACKGROUND: Children born preterm or with a small size for gestational age are at increased risk for childhood asthma. OBJECTIVE: We sought to assess the hypothesis that these associations are explained by reduced airway patency. METHODS: We used individual participant data of 24,938 children from 24 birth cohorts to examine and meta-analyze the associations of gestational age, size for gestational age, and infant weight gain with childhood lung function and asthma (age range, 3.9-19.1 years). Second, we explored whether these lung function outcomes mediated the associations of early growth characteristics with childhood asthma. RESULTS: Children born with a younger gestational age had a lower FEV1, FEV1/forced vital capacity (FVC) ratio, and forced expiratory volume after exhaling 75% of vital capacity (FEF75), whereas those born with a smaller size for gestational age at birth had a lower FEV1 but higher FEV1/FVC ratio (P