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EMBO Press, EMBO Reports, 7(14), p. 629-637, 2013

DOI: 10.1038/embor.2013.67

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Prdm14 promotes germline fate and naive pluripotency by repressing FGF signalling and DNA methylation

Journal article published in 2013 by Nils Grabole, Julia Tischler, Jamie A. Hackett, Shinseog Kim, Fuchou Tang, Harry G. Leitch, Erna Magnúsdóttir ORCID, M. Azim Surani, M. Azim Surani ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Primordial germ cells (PGCs) and somatic cells originate from postimplantation epiblast cells in mice. As pluripotency is lost upon differentiation of somatic lineages, a naive epigenome and the pluripotency network are re-established during PGC development. Here we demonstrate that Prdm14 contributes not only to PGC specification, but also to naive pluripotency in embryonic stem (ES) cells by repressing the DNA methylation machinery and fibroblast growth factor (FGF) signalling. This indicates a critical role for Prdm14 in programming PGCs and promoting pluripotency in ES cells.