Waste electrical and electronic equipment is one of the major world-wide waste streams triggering the emergence of environmental strategies. Environmental regulations, closed-loop supply chain (CLSC) activities and design-for-environment (DfE) practices are environmental friendly strategies being implemented by governments and industry. In this paper, we apply a System Dynamics model to a CLSC of electrical and electronic equipment in Greece. Extensive numerical investigation provides insights regarding the impact of different legislative measures, CLSC activities and DfE practices on the environmental (availability of natural resources and landfills) and economic sustainability.