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Elsevier, Phytochemistry, (85), p. 137-142

DOI: 10.1016/j.phytochem.2012.08.024

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Gastroprotective effect and structure of a rhamnogalacturonan from Acmella oleracea

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This paper is available in a repository.

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Abstract

The plant Acmella oleracea (L.) R.K.Jansen (Asteraceae), locally known as jambu, is widely used in Legal Amazon in local dishes and in folk medicine. A polysaccharide (SC) was isolated from this plant, following aqueous extraction, which contained uronic acid, galactose, arabinose, rhamnose, and glucose in a 15:2:1:1:0.5 molar ratio and had a M(w) 226,000g/mol. Methylation analysis and NMR spectroscopy indicated that SC is a rhamnogalacturonan composed of a long chain of →4)-6-OMe-α-d-GalpA-(1→, interspersed with some α-l-Rhap residues, partly substituted by side-chains of type II arabinogalactans. SC significantly inhibited ethanol-induced gastric ulcers in rats with an ED(50) of 1.5mg/kg, indicating that SC acts as gastroprotective agent.