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Springer Nature [academic journals on nature.com], Bone Marrow Transplantation, 1(25), p. 105-108, 2000

DOI: 10.1038/sj.bmt.1702093

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Fulminant hepatitis B following bone marrow transplantation in an HBsAg-negative, HBsAb-positive recipient; Reactivation of dormant virus during the immunosuppressive period

Journal article published in 2000 by K. Iwai, M. Tashi, M. Tashima, M. Itoh, T. Okazaki, K. Yamamoto, H. Ohno, H. Marusawa, Y. Ueda ORCID, T. Nakamura, T. Chiba, T. Uchiya, T. Uchiyama
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

It is widely accepted that seroconversion of HBsAg to HBsAb indicates clearance of hepatitis B virus. We describe a 50-year-old man with chronic myelocytic leukemia who developed lethal hepatitis B 22 months after allo-BMT. He had been negative for HBsAg and positive for HBsAb before BMT. Hepatitis B virus latently existing in the liver cells before BMT proliferated during the immunosuppressed period causing fatal hepatitis. Recipients with positive HBsAb should be considered to have the potential for active hepatitis B to emerge after BMT. Bone Marrow Transplantation (2000) 25, 105-108.