Published in
Royal Society of Chemistry, Chemical Communications, 44(51), p. 9105-9108
DOI: 10.1039/c5cc01536g
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A naphthalene diimide dyad for fluorescence switch-on detection of G-quadruplexes
Journal article published in 2015 by
F. Doria,
A. Oppi,
F. Manoli,
S. Botti,
N. Kandoth,
V. Grande,
I. Manet,
M. Freccero 
This paper is made freely available by the publisher.
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Abstract
A non-fluorescent naphthalene diimide (NDI) dimer, conjugating red and blue NDI dyes, becomes red/NIR emitting upon G-quadruplex binding. The fluorescence lifetime which is significantly different for the complexes, the G-quadruplex/dimer and the weakly emitting ds-DNA/dimer is the key feature for the development of new rationally engineered G-quadruplex sensors.