Published in
Royal Society of Chemistry, Organic and Biomolecular Chemistry, 28(12), p. 5235-5242, 2014
DOI: 10.1039/c4ob00149d
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Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue
Journal article published in 2014 by
M. Scuotto,
M. Persico,
M. Bucci,
V. Vellecco,
N. Borbone,
E. Morelli,
G. Oliviero,
E. Novellino,
G. Piccialli,
G. Cirino,
M. Varra,
C. Fattorusso 
,
L. Mayol
,
L. Mayol
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Abstract
Herein, we report optically pure modified acyclic nucleosides as ideal probes for aptamer modification. These new monomers offer unique advantages in exploring the role played in thrombin inhibition by a single residue modification at key positions of the TBA structure.