Impact of common variants of PPARG, KCNJ11, TCF7L2

Chauhan, Ganesh; Spurgeon, Charles J.; Tabassum, Rubina; Bhaskar, Seema; Kulkarni, Smita R.; Mahajan, Anubha; Chavali, Sreenivas; Kranthi Kumar, M. V.; Prakash, Swami; Dwivedi, Om Prakash; Ghosh, Saurabh; Yajnik, Chittaranjan S.; Tandon, Nikhil; Bharadwaj, Dwaipayan; Chandak, Giriraj R.

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Impact of common variants of PPARG, KCNJ11, TCF7L2

Journal article published in 2015 by Ganesh Chauhan, Charles J. Spurgeon, Rubina Tabassum, Seema Bhaskar, Smita R. Kulkarni, Anubha Mahajan, Sreenivas Chavali, M. V. Kranthi Kumar, Swami Prakash, Om Prakash Dwivedi, Saurabh Ghosh, Chittaranjan S. Yajnik, Nikhil Tandon, Dwaipayan Bharadwaj, Giriraj R. Chandak

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Abstract

OBJECTIVE Common variants in PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 genes have been shown to be associated with type 2 diabetes in European populations by genome-wide association studies. We have studied the association of common variants in these eight genes with type 2 diabetes and related traits in Indians by combining the data from two independent case–control studies.