Cell Press, Molecular Cell, 4(49), p. 583-590, 2013
DOI: 10.1016/j.molcel.2013.01.029
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High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours. Developments discussed in this Perspective will soon enable complete proteome analysis of mammalian cells, as well, with profound impact on biology and biomedicine.