A Helicase with an Extra Spring in Its Step
Journal article published in 2012 by
Michael Schlierf,
Taekjip Ha 
This paper is made freely available by the publisher.
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Abstract
DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.