Published in
Elsevier, Bioorganic and Medicinal Chemistry Letters, 7(24), p. 1802-1804, 2014
DOI: 10.1016/j.bmcl.2014.02.022
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Boseongazepines A-C, pyrrolobenzodiazepine derivatives from a Streptomyces sp 11A057
,
Soo-Jin Choo,
Sun-Ok Kim,
Jong Won Kim,
Sung-Kyun Ko,
Nak-Kyun Soung,
Jung-Sook Lee,
Chang-Jin Kim,
Hyuncheol Oh,
Young-Soo Hong,
Masashi Ueki,
Hiroshi Hirota,
Hiroyuki Osada,
Bo Yeon Kim
and other authors.
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Abstract
Three new pyrrolobenzodiazepine derivatives, boseongazepines A-C (1-3), were isolated from a culture broth of Streptomyces sp. 11A057, together with the known compound usabamycin B (4). The structures of 1-4 were determined through the analysis of spectroscopic data including extensive 1D-, 2D-NMR, and MS techniques. Cell growth inhibition effects of these compounds were evaluated against Jurkat, K-562, HL-60, and HepG2 cell lines.