Published in

British Institute of Radiology, British Journal of Radiology, 944(79), p. 688-701

DOI: 10.1259/bjr/67705974

Links

Tools

Export citation

Search in Google Scholar

Non-invasive measurement of perfusion: a critical review of arterial spin labelling techniques

Journal article published in 2006 by E. T. Petersen ORCID, I. Zimine, Y.-C. L. Ho, X. Golay
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Orange circle
Preprint: archiving restricted
Orange circle
Postprint: archiving restricted
Orange circle
Published version: archiving restricted
Data provided by SHERPA/RoMEO

Abstract

The non-invasive nature of arterial spin labelling (ASL) has opened a unique window into human brain function and perfusion physiology. High spatial and temporal resolution makes the technique very appealing not only for the diagnosis of vascular diseases, but also in basic neuroscience where the aim is to develop a more comprehensive picture of the physiological events accompanying neuronal activation. However, low signal-to-noise ratio and the complexity of flow quantification make ASL one of the more demanding disciplines within MRI. In this review, the theoretical background and main implementations of ASL are revisited. In particular, the perfusion quantification methods, including the problems and pitfalls involved, are thoroughly discussed in this article. Finally, a brief summary of applications is provided.