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Oxford University Press, European Heart Journal, 36(35), p. 2468-2476, 2014

DOI: 10.1093/eurheartj/ehu235

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Iron deficiency defined as depleted iron stores accompanied by unmet cellular iron requirements identifies patients at the highest risk of death after an episode of acute heart failure

Journal article published in 2014 by Ewa A. Jankowska, Robert Zymliński, Monika Kasztura, Mateusz Sokolski ORCID, Marek Bronisz, Sylwia Nawrocka, Weronika Oleśkowska-Florek, R. Zymli ski, Jan Biegus, P. Siwo owski, Paweł Siwołowski, Waldemar Banasiak, Stefan D. Anker, Gerasimos Filippatos, John G. F. Cleland and other authors.
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Aim: Acute heart failure (AHF) critically deranges haemodynamic and metabolic homoeostasis. Iron is a key micronutrient for homoeostasis maintenance. We hypothesized that iron deficiency (ID) defined as depleted iron stores accompanied by unmet cellular iron requirements would in this setting predict the poor outcome. Methods and results: Among 165 AHF patients (age 65 ± 12 years, 81% men, 31% de novo HF), for ID diagnosis we prospectively applied: low serum hepcidin reflecting depleted iron stores (