A strength of the field of cognitive engineering and decision-making lies in its wide applica-bility across the complex socio-technical systems, which are ubiquitous in modern society. Meth-ods and theoretical advances in CEDM have been both developed through, and adapted across, domains as diverse as nuclear power, health systems, and aviation. While all of these domains clearly differ in terms of their surface characteristics, cognitive engineers are able to make funda-mental connections across domains. These connections are supported by the types of methodological tools deployed within CEDM and allow problem solutions to be extended and adapted across domains. This panel brings together researchers and practitioners who have worked in a wide vari-ety of domains to discuss a variety of design and methodological challenges they have and are facing. The panel will focus on synthesizing these challenges across domains – both across the panellists, and members of the audience, with the goal of providing both guidance and direction for future research.