Published in
Elsevier, Tetrahedron, 30-31(64), p. 7127-7130, 2008
DOI: 10.1016/j.tet.2008.05.037
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Jaspamides H–L, new actin-targeting depsipeptides from the sponge Jaspis splendans
Journal article published in 2008 by
Fulvio Gala,
Maria Valeria D'Auria,
Simona De Marino 
,
Valentina Sepe,
Franco Zollo,
Charles D. Smith,
Jean E. Copper,
Angela Zampella
,
Valentina Sepe,
Franco Zollo,
Charles D. Smith,
Jean E. Copper,
Angela Zampella
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Abstract
Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H–L (2–5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.Graphical abstract