Published in
Nature Research, Nature Immunology, 6(10), p. 566-568, 2009
DOI: 10.1038/ni0609-566
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Antigen-processing and presentation pathways select antigenic HIV peptides in the fight against viral evolution
Journal article published in 2009 by
David H. Margulies 
This paper is made freely available by the publisher.
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Abstract
The evolution of immunodominant epitopes in HIV-1 Gag proteins correlates with quantitative measures of several antigen processing events. Thus, peptides recognized by CD8(+) cytolytic T cells are selected by their ability to pass through the antigen processing pathway, as well as by their binding to HLA molecules.