Published in
Royal Society of Chemistry, New Journal of Chemistry, 8(39), p. 5931-5935, 2015
DOI: 10.1039/c5nj01325a
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Aggregating distyrylpyridinium dye as a bimodal structural probe for G-quadruplex DNA
Journal article published in 2015 by
Xiao Xie,
Aurélie Renvoisé,
Anton Granzhan,
Marie-Paule Teulade-Fichou
This paper is available in a repository.
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Abstract
A colorimetric and fluorimetric probe for the detection of G-quadruplex (G4) DNA was designed by the introduction of coumarin units into the distyrylpyridinium chromophore. It has been successfully applied for the optical discrimination of G4 vs. non-G4 DNA and validated using two previously unknown G4-forming sequences, which were identified in the genome of Mycobacterium tuberculosis.