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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 4(58), p. 2415-2417, 2014

DOI: 10.1128/aac.02438-13

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Mechanism of Resistance to an Antitubercular 2-Thiopyridine Derivative That Is Also Active against Burkholderia cenocepacia

Journal article published in 2014 by Viola C. Scoffone, Francesca Spadaro, Claudia Udine, Vadim Makarov, Marco Fondi, Renato Fani, Edda De Rossi, Giovanna Riccardi, Silvia Buroni
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT The discovery of new compounds that are able to inhibit the growth of Burkholderia cenocepacia is of primary importance for cystic fibrosis patients. Here, the mechanism of resistance to a new pyridine derivative already shown to be effective against Mycobacterium tuberculosis and to have good activity toward B. cenocepacia was investigated. Increased expression of a resistance-nodulation-cell division (RND) efflux system was detected in the resistant mutants, thus confirming their important roles in B. cenocepacia antibiotic resistance.