The ability of marine brown algae Sargassum myriocystum for sorption of Cu(II) ions from aqueous solution was studied in batch experiments. The effect of relevant parameters such as function of pH, sorbent dosage, agitation speed and contact time was evaluated by using Response surface methodology (RSM). A maximum percentage removal of Cu (II) by Sargassum myriocystum occurs at pH-4.94, sorbent dosage – 1.99 g/L, agitation speed – 119.59 rpm and contact time – 59.55 min.