Published in
Elsevier, Tetrahedron, 24(63), p. 5212-5219, 2007
DOI: 10.1016/j.tet.2007.03.162
Wiley-VCH Verlag, ChemInform, 38(38), 2007
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New Jaspamide Derivatives with Antimicrofilament Activity from the Sponge Jaspis splendans
Journal article published in 2007 by
Fulvio Gala,
Maria Valeria D'Auria,
Simona De Marino 
,
Franco Zollo,
Charles D. Smith,
Jean E. Copper,
Angela Zampella
,
Franco Zollo,
Charles D. Smith,
Jean E. Copper,
Angela Zampella
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Abstract
A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D–G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.