Published in
Elsevier, Lancet Haematology, 2(2), p. e55-e65
DOI: 10.1016/s2352-3026(14)00039-8
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Non-invasive detection of genomic imbalances in Hodgkin/Reed-Sternberg cells in early and advanced stage Hodgkin's lymphoma by sequencing of circulating cell-free DNA: A technical proof-of-principle study
,
Luc Dehaspe,
Daan Dierickx,
Magali Verheecke,
Anne Uyttebroeck,
Oliver Bechter,
Michel Delforge,
Vincent Vandecaveye,
Nathalie Brison,
Gregor Eg Verhoef,
Eric Legius,
Frederic Amant
and other authors.
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Abstract
Hodgkin's lymphoma is one of the most common lymphoid neoplasms in young adults, but the low abundance of neoplastic Hodgkin/Reed-Sternberg cells in the tumour hampers the elucidation of its pathogenesis, biology, and diversity. After an incidental observation that genomic aberrations known to occur in Hodgkin's lymphoma were detectable in circulating cell-free DNA, this study was undertaken to investigate whether circulating cell-free DNA can be informative about genomic imbalances in Hodgkin's lymphoma.